ANGIOTENSIN RECEPTOR BLOCKERS | AT1 RECEPTOR ANTAGONIST | MECHANISM OF ACTION | USES

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Издатель Nov 23, 2020

ANGIOTENSIN RECEPTOR BLOCKERS | AT1 RECEPTOR ANTAGONIST | MECHANISM OF ACTION | USES | SIDE EFFECTS

ANGIOTENSIN RECEPTOR BLOCKERS (ARBs)
Angiotensin receptor blockers (ARBs), also known as angiotensin II receptor antagonists, are used to treat high blood pressure and heart failure.
They are also used for chronic kidney disease and prescribed following a heart attack.
Popular medication in this class are valsartan, losartan, candesartan.

AT1 RECEPTOR
The angiotensin II type 1 receptor (AT1 receptor) is one of the key players in the renin angiotensin aldosterone system.

AT1 RECEPTOR
The AT1 receptor promotes various intracellular signaling pathways resulting in
Hypertension
Endothelial dysfunction
Vascular remodeling
End organ damage.

ANGIOTENSIN RECEPTOR BLOCKERS (ARBs)
ANGIOTENSIN RECEPTOR BLOCKERS (ARBs) Drugs block this AT1 receptor resulting
Vasodilation
Decrease in blood pressure

ANGIOTENSIN RECEPTOR BLOCKERS (RX ONLY)
Losartan,
Valsartan,
Azilsartan,
Candesartan,
Eprosartan,
Irbesartan,
Olmesartan,
Telmisartan,

ANGIOTENSIN RECEPTOR BLOCKERS DAILY DOSE

MECHANISM OF ACTION OF ANGIOTENSIN RECEPTOR BLOCKERS ARBs
AT1-receptor blockers bind selectively to AT1- receptors and thus inhibit the effects of angiotensin II, irrespective of whether angiotensin II is produced via angiotensin converting enzyme (ACE) or by non-ACE pathways.

USE AND INDICATIONS OF ANGIOTENSIN RECEPTOR BLOCKERS
Controlling high blood pressure.
Treating congestive heart failure,
preventing diabetes or high blood pressure-related kidney failure,
reducing the risk of stroke in patients with hypertension and an enlarged heart.

SIDE EFFECTS OF ANGIOTENSIN RECEPTOR BLOCKERS
Dizziness
Lightheadedness
Faintness upon rising
Confusion
Diarrhea
Muscle cramps
Weakness
Sinusitis
Back or leg pain,
Insomnia
Difficulty sleeping
Irregular heartbeat
Cough (less than ACEI)
Myocardial infarction
Risk of Cancer
Risk of Kidney failure

CONTRAINDICATIONS OF ANGIOTENSIN RECEPTOR BLOCKERS
ARBs are contraindicated in pregnancy.
Patients with bilateral renal artery stenosis may experience renal failure if ARBs are administered.
Teratogenic during pregnancy
Breastfeeding
Hypersensitivity to ARBs

WARNINGS OF ANGIOTENSIN RECEPTOR BLOCKERS
WARNING TO AVOID COMBINATION OF ARBS & RENIN INHIBITORS
SO, Don’t make combination with renin inhibitors Due to risk of
The risks of kidney (renal) impairment
Low blood pressure (hypotension)
High potassium blood levels (hyperkalemia)

#Losartan
#Valsartan
#Azilsartan
#Candesartan
#Eprosartan.
#Irbesartan
#Olmesartan
#Telmisartan